Cummings, Elizabeth, Donohoe, Gary, Hargreaves, April, Moore, Susan, Fahey, Ciara, Dinan, T. G., McDonald, C., O'Callaghan, E., O'Neill, F. A., Waddington, J. L., Murphy, K. C., Morris, Derek, Gill, Michael and Corvin, Aiden (2013) Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137. Neuroscience Letters, 532. pp. 33-38. ISSN 0304-3940Full text not available from this repository.
The Schizophrenia Psychiatric Genome-wide Association (GWAS) Consortium recently reported on five novel schizophrenia susceptibility loci. The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes.
We genotyped 821 patients with confirmed DSM-IV diagnoses of schizophrenia, bipolar affective disorder I and schizoaffective disorder for the risk SNP (rs1625579) and investigated the clinical profiles of risk allele carriers using a within-case design. We also assessed neurocognitive performance in a subset of cases (n = 399) and controls (n = 171).
Carriers of the risk allele had lower scores for an OPCRIT-derived positive symptom factor (p = 0.04) and lower scores on a lifetime measure of psychosis incongruity (p = 0.017). Risk allele carriers also had more cognitive deficits involving episodic memory and attentional control.
This is the first evidence that the MIR-137 risk variant may be associated with a specific subgroup of psychosis patients. Although the effect of this single SNP was not clinically relevant, investigation of the impact of carrying multiple risk SNPs in the MIR-137 regulatory network on diagnosis and illness profile may be warranted.
► We investigated the clinical symptom profiles of carriers of the schizophrenia mir137 risk allele. ► The sample included 821 patients with schizophrenia, schizoaffective disorder and bipolar I disorder. ► Risk allele carriers had lower scores for positive symptoms and less psychosis incongruity. ► On neurocognitive testing in a subset, there were more cognitive deficits in risk allele carriers.
|Subjects:||B Philosophy. Psychology. Religion > Psychology
B Philosophy. Psychology. Religion > Psychology > Cognition
|Divisions:||School of Business > Staff Research and Publications|
|Depositing User:||CAOIMHE NI MHAICIN|
|Date Deposited:||12 Apr 2016 18:54|
|Last Modified:||12 Apr 2016 18:54|
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